Jekyll and Hide
نویسندگان
چکیده
منابع مشابه
Jekyll and Hide
Neurodegenerative diseases are a burden of our century. Although significant efforts were made to find a cure or relief to this scourge, their pathophysiology remains vague and the cellular function of the key involved proteins is still unclear. However, in the case of amyloid β (Aβ), a key protein concerned in Alzheimer disease, we are now a step closer in the unscrambling of its cellular func...
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Polyploidization is a state in which cells possess more than two sets of homologous chromosomes, which occurs frequently in nature [1]. In Mammals, whole organism polyploidy is usually lethal; however, some tissues develop a certain degree of polyploidy during their normal lifecycle. Polyploid cells are generated because of cell fusion or abnormal cell division (e.g. endoreplication, mitotic sl...
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Uric acid (UA) is a potent endogenous antioxidant. However, high concentrations of this molecule have been associated with cardiovascular disease (CVD) and renal dysfunction, involving mechanisms that include oxidative stress, inflammatory processes, and endothelial injury. Experimental and in vitro results suggest that this biomarker behaves like other antioxidants, which can shift from the ph...
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Data extraction: Data were extracted from FDA and sponsor documents and corroborated with published articles when available. Thirty-day survival was assessed by metaanalysis using a fixed-effects model and time-dependent risk by Kaplan-Meier analysis with Cox proportional hazards regression modeling. Where deaths were described within a range of days after treatment, an extreme assumption was m...
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ژورنال
عنوان ژورنال: Communicative & Integrative Biology
سال: 2012
ISSN: 1942-0889
DOI: 10.4161/cib.22571